王芸芸
师资介绍
王芸芸，女，1991.01，讲师，博士研究生，专任教师
研究方向：主要从事天然产物的结构修饰、靶点的发现以及基于计算机辅助药物设计的研究。
基金项目：
1、江苏省自然科学基金项目, 青年基金项目，BK20220611，2022.0—2025.06，主持，在研；
2、bat365中文官网登录入口人才引进项目，2022.5-2025.04，主持，在研；
3、国家自然科学基金委员会, 地区科学基金项目, 32260370, 2023.01— 2026.12, 在研, 参与；
4、国家自然科学基金委员会, 面上项目, 32071707, 2021.01—2024.12, 在研, 参与。
代表性论文：
(1) Jianmin Wang, Jiashun Mao, Meng Wang, Xiangyang Le, Yunyun Wang*. Learning to design drug-like molecules in three-dimensional space using deep generative models, Methods, 2023, 210: 52-59;
(2) Jiashun Mao*, Jianmin Wang, Amir Zeb, Kwang-Hwi Cho, Kwang-Hwi Cho, Haiyan Jin, Jongwan Kim, Onju Lee, Yunyun Wang*, and Kyoung Tai No*. Transformer-Based Molecular Generative Model for Antiviral Drug Design. J. Chem. Inf. Model. 2023, https://doi.org/10.1021/acs.jcim.3c00536.
(3) Zhongyuan Xu, Jianqiang Qian, Chi Meng, Yun Liu, Qian Ding, Hongmei Wu, Peng Li, Fansheng Ran, Gongqing Liu, Yunyun Wang*, Yong Ling*. TME-targeting theranostic agent uses NIR tracking for tumor diagnosis and surgical resection and acts as chemotherapeutic showing enhanced efficiency and minimal toxicity, Theranostics, 2022, 12(6): 2535-2548;
(4) Yunyun Wang, Wei Shi, Yuxun Zhao, Chenglong Zhang, Lin Wan, Chenliang Wu, Wen Gu, Shifa Wang*. Pyrazole ring-containing isolongifolanone derivatives as potential CDK2 inhibitors: Evaluation of anticancer activity and investigation of action mechanism, Biomedicine &pharmacotherapy, 2021, 139: 111663;
(5) Yunyun Wang, Zhonglong Wang, Hongbo Kuang, Yan Zhang, Wen Gu, Yongqiang Zhu, Shifa Wang. Synthesis and antitumor activity of 2-isocamphanyl thiosemicarbazone derivatives via ROS-enhanced mitochondria damage, Chemical Biology & Drug Design, 2019, 94(1): 1281-1291;
(6) Yunyun Wang, Qiangjian Zhang, Chenliang Wu, Wen Gu, Yu Shan, Shifa Wang*. Design, synthesis and biological evaluation of novel β-pinene-based thiazole derivatives as potential anticancer agents via mitochondrial-mediated apoptosis pathway. Bioorganic chemistry, 2019, 84: 468-477.
(7) Yunyun Wang, Wen Gu, Yu Shan, Fei Liu, Xu Xu, Yiqin Yang, Qiangjian Zhang, Yan Zhang, Hongbo Kuang, Zhonglong Wang, Shifa Wang*. Design, synthesis and anticancer activity of novel nopinone-based thiosemicarbazone derivatives. Bioorganic & Medicinal Chemistry Letters, 2017, 27(11), 2360-2363.