范博义

师资介绍

姓名：范博义

性别：男

民族：汉

出生年月：1989.01

职称：副教授

学历：博士

职务：天然药物与药物分析系副主任

研究方向：活性天然产物的开发利用

社会学术兼职：无

基金项目：

1. 国家自然科学基金面上项目，树脂糖苷类Sec61α抑制剂的发现及其潜在抗冠状病毒活性研究，2024.01-2027.12，主持

2. 南通市科技项目，香樟叶中天然活性化合物的发现及其药理机制研究，2021.07-2023.06，主持

3. 国家自然科学基金青年项目，基于自噬-溶酶体通路的土丁桂中潜在抗阿尔茨海默症树脂糖苷类成分的发现及其作用机制研究，2019.01-2021.12，主持

4. 南通市科技项目，土丁桂中新颖抗AD活性成分及作用机制研究，2016.10-2018.09，主持

科研成果：

1. 范博义，赵文迪，陆云，杨敏。田旋花总树脂糖苷提取物及其制备方法和医学用途，专利号：ZL201810244054.0。

代表性论文：

1. Yan-Ni Wu, You-Jia Lu, Ying Yi, An-Dong Wang, Wen-Li Wang, Min Yang, Bo-Yi Fan*, Guang-Tong Chen* Biotransformation of asiatic acid by Cunninghamella echinulata and Circinella muscae to discover anti-neuroinflammatory derivatives. Natural Product Research, 2023, 37(16), 2712-2717.

2. Xing Jiang^#, Xi-Han Zhang^#, Yu-Xin Li, Kai Chen, Bin Lin, Tian-Qi Lu, Min Yang, Guang-Tong Chen, Bo-Yi Fan*, Wen-Li Wang*. Chemical constituents from the leaves of Cinnamomum camphora and their α-glucosidase inhibitory activities. Phytochemistry Letters 2023, 57, 101–105.

3. Bo-Yi Fan^#*, Xing Jiang^#, Yu-Xin Li, Wen-Li Wang, Min Yang, Jian-Lin Li, An-Dong Wang, Guang-Tong Chen*. Chemistry and biological activity of resin glycosides from Convolvulaceae species. Medicinal Research Reviews 2022, 42(6), 2025-2066. 

4. Wen-Li Wang^#, Yu-Xin Li^#, Ye He^#, Xing Jiang, Ying Yi, Xi-Han Zhang, Shi-Yu Zhang, Guang-Tong Chen, Min Yang, Jia-Lie Luo, Bo-Yi Fan*. Progress in the total synthesis of resin glycosides. Frontiers in Chemistry 2022, 10, 1036954. 

5. You-Jia Lu^#, Yi-Fei Tang^#, Yan-Ni Wu, Xue-Ying Zhang, Ying Yi, Wen-Li Wang*, An-Dong Wang, Min Yang, Bo-Yi Fan*, Guang-Tong Chen*. Microbial transformation of betulonic acid by Circinella muscae CGMCC 3.2695 and anti-neuroinflammatory activity of the products. Phytochemistry 2022, 204, 113431. 

6. Cheng-Jiao Chu^#, Kai-Nan Song^#, Yong-Zhen Zhang, Min Yang, Bo-Yi Fan*, Hui-Lian Huang and Guang-Tong Chen*. Biotransformation of ursolic acid by Circinella muscae and their anti-neuroinflammatory activities of metabolites. Natural Product Research 2022, 36(11), 2777-2782.

7. Kai-Nan Song^#, You-Jia Lu^#, Cheng-Jiao Chu, Yan-Ni Wu, Hui-Lian Huang, Bo-Yi Fan*, and Guang-Tong Chen*. Biotransformation of betulonic acid by the fungus Rhizopus arrhizus CGMCC 3.868 and antineuroinflammatory activity of the biotransformation products. Journal of Natural Products 2021, 84(10), 2664–2674. 

8. Jin-Yuan Xu^#, Ye He^#, Ai-Wen Zhang, Yun Lu, Guang-Tong Chen, Min Yang, Bo-Yi Fan*. Isolation of evolvulic acids B and C, two new components of crude resin glycoside fraction from Evolvulus alsinoides. Natural Product Research 2021,35(21), 3766-3771.

9. Yun Lu^#, Ye He^#, Min Yang, Bo-Yi Fan*. Arvensic acids K and L, components of resin glycoside fraction from Convolvulus arvensis. Natural Product Research 2021, 35(14), 2303-2307.

10. Bo-Yi Fan*, Yun Lu, Jin-Yuan Xu, Ai-Wen Zhang, Min Yang, Guang-Tong Chen. Evolvulin III, a new resin glycoside isolated from Evolvulus alsinoides. Phytochemistry Letters 2020, 39, 132–134

11.Bo-Yi Fan, Yun Lu, Min Yang, Jian-Lin Li*, Guang-Tong Chen*. Evolvulins I and II, resin glycosides with a trihydroxy aglycone unit from Evolvulus alsinoides. Organic Letters 2019, 21, 6548–6551.

12. Bo-Yi Fan, Ye He, Yun Lu, Min Yang, Qing Zhu, Guang-Tong Chen*, Jian-Lin Li*. Glycosidic acids with unusual aglycone units from Convolvulus arvensis. Journal of Natural Products 2019, 82, 1593-1598.

13. Bo-Yi Fan, Bao-Cheng Jiang, Sen-Sen Yan, Bo-Hui Xu, Hui-Lian Huang, Guang-Tong Chen* Anti-inflammatory 18β-glycyrrhetinin acid derivatives produced by biocatalysis. Planta Medica 2019, 85, 56-61.

14. Jian-Lin Li, Xin Jiang, Xin-Pei Liu, Cai-Wei He, Yu-Xin Di, Sai-Jian Lu, Hui-Lian Huang, Bin Lin, Dong Wang*, Bo-Yi Fan*. Antibacterial anthraquinone dimers from marine derived fungus Aspergillus sp. Fitoterapia 2019, 133, 1-4.

15. Guang-Tong Chen, Yun Lu, Min Yang, Jian-Lin Li*, Bo-Yi Fan*. Medicinal uses, pharmacology, and phytochemistry of Convolvulaceae plants with central nervous system efficacies: a systematic review. Phytotherapy Research 2018, 32(5), 823-864.

16. Bo-Yi Fan^#, Yun Lu^#, Hong Yin, Ye He, Jian-Lin Li*, Guang-Tong Chen*. Arvensic acids A-D, novel heptasaccharide glycosidic acids as the alkaline hydrolysis products of crude resin glycosides from Convolvulus arvensis. Fitoterapia 2018, 131, 209-214. 

17. Bo-Yi Fan, Zhong-Rui Li, Ting Ma, Yu-Cheng Gu, Hui-Jun Zhao, Jian-Guang Luo*, Ling-Yi Kong*. Further screening of the resin glycosides in the edible water spinach and characterisation on their mechanism of anticancer potential. Journal of Functional Foods 2015, 19, 141-154. 

18. Bo-Yi Fan, Yu-Cheng Gu, Ye He, Zhong-Rui Li, Jian-Guang Luo,* Ling-Yi Kong*. Cytotoxic resin glycosides from Ipomoea aquatica and their effects on intracellular Ca²⁺ concentrations. Journal of Natural Products 2014, 77, 2264−2272.

19. Bo-Yi Fan, Jian-Guang Luo, Yu-Cheng Gu, Ling-Yi Kong*. Unusual ether-type resin glycoside dimers from the seeds of Cuscuta chinensis. Tetrahedron 2014, 70, 2003-2014.